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What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease
  • high blood cholesterol or triglycerides
  • nflammatory bowel disease
  • liver disease
  • mental problems, such as depression, psychosis, attempted suicide, or a family history of mental problems
  • osteoporosis, osteomalacia, or other bone disorders
  • pancreatitis
  • an unusual or allergic reaction to isotretinoin, vitamin A or related drugs, parabens, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
  • How should I use this medicine?

    Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow these tablets whole. Do not chew, crush, or divide them. If this medicine upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed.
    Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years of age, precautions do apply.
    Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

    What if I miss a dose?

    If you miss a dose, take it as soon as you can. If it is less than four hours to your next dose, take only that dose and skip the missed dose. Do not take double or extra doses.

    What may interact with this medicine?

    Do not take this medicine with any of the following medications:

  • vitamins and other supplements containing vitamin A
  • This medicine may also interact with the following medications:

  • alcohol
  • benzoyl peroxide, salicylic acid, or other drying medicines used for acne
  • medicines for seizures
  • orlistat
  • other drugs that make you more sensitive to the sun such as sulfa drugs
  • progestin-only birth control hormones
  • st. john's wort
  • steroid medicines like prednisone or cortisone
  • tetracycline antibiotics like doxycycline and tetracycline
  • warfarin
  • This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

    What should I watch for while using this medicine?

    You may experience a flare in your acne during the initial treatment period. You will need to see your doctor or health care professional monthly to get a new prescription and to check on your progress and for side effects.
    Do not give blood while taking this medicine and for 30 days after completion of treatment to avoid exposing pregnant women to this medicine through the donated blood.
    Some patients have become depressed or developed serious mental problems while taking this medicine or soon after stopping. Stop taking this medicine if you start feeling depressed or have thoughts of violence or suicide. Contact your doctor.
    If you wear contact lenses, they may feel uncomfortable. If your eyes get dry, check with your eye doctor. This medicine may decrease your night vision or cause other changes in vision. If you experience any change in vision, stop taking this medicine and see an eye doctor.
    This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
    Cosmetic procedures to smooth your skin including waxing, dermabrasion, or laser therapy should be avoided during therapy and for at least 6 months after you stop because of the possibility of scarring. Check with your health care provider for advice about when you can have cosmetic procedures.
    This medicine may affect your blood sugar levels. If you have diabetes check with your doctor or health care professional if you notice any change in your blood sugar tests.

    What side effects may I notice from receiving this medicine?

    Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in menstrual cycle
  • changes in vision, like blurred or double vision or decreased night vision
  • chest pain
  • depression
  • dizziness
  • fainting
  • hearing loss or ringing in the ears
  • hives, skin rash
  • ncreased irritability, anger, aggression or thoughts of violence
  • ncreased urination and/or thirst or dark urine
  • rregular heartbeat
  • loss of interest in usual activities
  • muscle or joint pain
  • muscle weakness with or without pain
  • nausea and vomiting
  • severe diarrhea
  • severe headache
  • severe stomach pain
  • slurred speech or trouble swallowing
  • start to have thoughts about hurting yourself
  • swelling of face or mouth
  • unusual bruising or bleeding
  • yellowing of the eyes or skin
  • Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • chapped lips
  • dry mouth, nose or skin
  • flushing
  • hair loss, increased fragility of hair
  • headache (mild)
  • Where should I keep my medicine?

    Keep out of the reach of children.
    Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

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